Effective Than its Long-Term Administration for the Treatment of Neonatal Hypoxic Short-Term Administration of a New Free Radical Scavenger, Edaravone, Is More
نویسندگان
چکیده
Jesmin I. Noor, Tomoaki Ikeda, Kenichi Mishima, Naoya Aoo, Sumie Ohta, Nobuaki Egashira, Ischemic Encephalopathy − Effective Than its Long-Term Administration for the Treatment of Neonatal Hypoxic Short-Term Administration of a New Free Radical Scavenger, Edaravone, Is More Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.0000185653.49740.c6 2005;36:2468-2474; originally published online October 6, 2005; Stroke. http://stroke.ahajournals.org/content/36/11/2468 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Short-term administration of a new free radical scavenger, edaravone, is more effective than its long-term administration for the treatment of neonatal hypoxic-ischemic encephalopathy.
BACKGROUND AND PURPOSE Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a new free radical scavenger that is used for the treatment of adult acute cerebral infarction in Japan. We examined the effect of edaravone on the optimal duration of treatment, the long-term effect on the brain, and the effect on learning and memory disability in a rat model of neonatal hypoxic-ischemic encephalopathy. ...
متن کاملProtective Effect of Short-term Administration of Ethanolic Saffron Extract on improvement of Cognitive Deficits and Decrement of Lipid Peroxidation induced by Ethidium Bromide in Experimental Models of MS
Introduction: Cognitive dysfunction is recognized as a significant feature of multiple sclerosis (MS). Oxidative stress plays an important role in the pathogenesis of MS. Toxic demyelination by ethidium bromide (EB) is one of the common methods for induction of MS, which leads to neuronal death by production of free radicals and enhancement of oxidative stress burden. According to previous p...
متن کاملThe Study of Histomorphometry and Histochemistry of Liver in Adult Male and Female Rats Following Short-term and Long-term Administration of Methylphenidate
Background & Objective: Methylphenidate is one of the most common medications used for treatment of attention-deficit/hyperactivity disorder (ADHD). The administration of methylphenidate, through blocking of dopamine receptors and increment of extracellular dopamine levels, leads to escalation in central nervous system activity. Numerous studies investigated the effect of methylphenidate on bod...
متن کاملLong-term efficacy of edaravone in patients with acute myocardial infarction.
BACKGROUND The effect of edaravone, a free radical scavenger, on long-term prognosis and its efficacy with regards to scavenging injurious free radicals in patients with acute myocardial infarction (AMI) was examined. METHODS AND RESULTS One hundred and one initial AMI patients were randomly assigned to receive 30 mg edaravone (n = 50) or a placebo (n = 51) intravenously just before reperfusi...
متن کاملAge-Related Changes in Doxorubicin-Induced Oxidative Damage: Protective and Pretreatment Effects of Short-Term Aerobic Exercise
ABSTRACT Background and Objective: Doxorubicin (DOX) is an effective anticancer drug. It has been shown that a short-term exercise performed prior to DOX-treatment has no effect on cardiotoxicity in young rats. In the present study, old and young rats were evaluated to determine the protective effects of pre-treatment with short-term exercise on D...
متن کامل